B23 Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 10306-1-AP

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Freight/Packing

Con: 30 μg/150 μl

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Species specificity:
human, rat, mouse

Positive WB detected in:
multi-cells, C6 cells, HEK-293 cells, HeLa cells, Jurkat cells, K-562 cells

Positive IP detected in:
Jurkat cells

Positive IHC detected in:
human colon cancer tissue, human breast cancer tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:1000-1:4000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
nucleophosmin (nucleolar phosphoprotein B23, numatrin)

Calculated molecular weight:
33 kDa

Observed molecular weight:
35-40 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
NPM1

Synonyms
B23, NPM1, Nucleolar phosphoprotein B23, Nucleolar protein NO38, Nucleophosmin, Numatrin
Background

Nucleophosmin (NPM1,B23) is a putative ribosome assembly factor with a high affinity for peptides containing nuclear localization signals (NLSs). The transport of proteins across the nuclear envelope is a selective, multistep process involving several cytoplasmic factors. Proteins must be recognized as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Several cytosolic and nuclear proteins that are central to this process have been identified. The 38 kDa nuclear protein nucleophosmin is involved in ribosomal assembly and rRNA transport. It is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis.


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