OTUD7B Antibody 5 Publications

Rabbit Polyclonal| Catalog number: 16605-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 33 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Jurkat cells

Positive IP detected in:
Jurkat cells

Positive IHC detected in:
human kidney tissue,human heart tissue, mouse kidney tissue, mouse heart tissue

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
OTU domain containing 7B

Calculated molecular weight:
427aa,48 kDa;843aa,93 kDa

Observed molecular weight:
100 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
OTUD7B

Synonyms
CEZANNE, OTU domain containing 7B, OTU7B, OTUD7B, ZA20D1, Zinc finger protein Cezanne
Background

OUTD7B is a member of the A20 family of the deubiquitinating cysteine proteases, which has deubiquitinating activity that is directed towards 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. It plays a key role in the negative feedback regulation of NF-κB signaling in response to multiple stimuli and has been described as central gatekeeper in inflammation and immunity. The calculated molecular weight of OTUD7Bis 93 kDa, but the modified OTUD7B is about 100 kDa.


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