P27; KIP1 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 26714-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 115 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
NIH/3T3 cells, HeLa cells, MCF-7 cells

Positive IHC detected in:
human gliomas tissue, human breast cancer tissue, human colon cancer tissue, human lung cancer tissue, human ovary tumor tissue, human tonsillitis tissue

Recommended dilution:
WB : 1:2000-1:8000
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Calculated molecular weight:
198aa,22 kDa

Observed molecular weight:
27 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CDKN1B

Synonyms
CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27, P27; KIP1, P27KIP1
Background

CDKN1B, also named as P27 or KIP1, is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. P27 binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controlling cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Downregulation of P27 has been implicated in the progression of several malignancies, including lung cancer, hepatocellular carcinoma, salivary cancer, oral squamous cell carcinomas, and gastric cancer.


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