PARK7,DJ-1 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 11681-1-AP

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Freight/Packing

Con: 82 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HeLa cells, HEK-293 cells, Jurkat cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human gliomas tissue, human kidney tissue

Positive IF detected in:
SH-SY5Y cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
Parkinson disease (autosomal recessive, early onset) 7

Calculated molecular weight:
189aa,20 kDa

Observed molecular weight:
20 kDa, 25 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PARK7

Synonyms
DJ 1, DJ1, FLJ27376, FLJ34360, FLJ92274, Oncogene DJ1, PARK7, Parkinson disease protein 7, Protein DJ 1
Background

PARK7, also named as DJ1, belongs to the peptidase C56 family. It protects cells against oxidative stress and cell death. PARK7 plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. It eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. PARK7 has cell-growth promoting activity and transforming activity. It may function as a redox-sensitive chaperone. It's precursor undergoes a cleavage of a C-terminal peptide and subsequent activation of protease activity in response to oxidative stress. The amino acid replace at 166 (L → P) reduces PARK7 protein stability and leads to increased degradation.


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