PTP1B Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 11334-1-AP

Featured Product KD/KO validated

  • Print page
  • Download PDF

Be the first to review this product


-_-

Freight/Packing

Con: 52 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse, rat

Positive WB detected in:
Jurkat cells,A431 cells, human testis tissue, HL-60 cells, PC-3 cells, human placenta tissue, BxPC-3 cells

Positive IP detected in:
A431 cells

Positive IHC detected in:
human prostate cancer tissue

Positive IF detected in:
BxPC-3 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
protein tyrosine phosphatase, non-receptor type 1

Calculated molecular weight:
435aa,50 kDa

Observed molecular weight:
45-55 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PTPN1

Synonyms
PTP 1B, PTP1B, PTPN1
Background

PTPN1 (protein tyrosine phosphatase, non-receptor type 1) is also named as PTP1B or PTP-1B, and belongs to the protein-tyrosine phosphatase family and non-receptor class 1 subfamily. PTPN1 is involved in the regulation of several important physiological pathways, which regulates both insulin and leptin signaling, and interacts with the epidermal-and platelet-derived growth factor receptors (PMID: 20101100). The gene might harbor variants influencing susceptibility to insulin resistance and type 2 diabetes (PMID:15919813). The molecular mass of PTPN1 is 50 kDa, but sometimes some truncated forms can be detected as 48, 46, 39, 37 kDa due to non-specific proteolytic cleavage of PTP1B in different cells (PMID: 18253097).


Back
to top