- Featured Product
- KD/KO Validated
QKI Polyclonal Antibody for IP, WB, ELISA
Cat no : 13169-1-AP
HKQ, Hqk, HqkI, Protein quaking, QK, QK1, QK3, QKI
|Positive WB detected in||Neuro-2a cells|
|Positive IP detected in||K-562 cells|
|Western Blot (WB)||WB : 1:500-1:3000|
|Immunoprecipitation (IP)||IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB|
|Sample-dependent, check data in validation data gallery|
13169-1-AP targets QKI in WB, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||QKI fusion protein Ag3822|
|Full Name||quaking homolog, KH domain RNA binding (mouse)|
|Calculated molecular weight||341aa,38 kDa|
|Observed molecular weight||38 kDa|
|GenBank accession number||BC019917|
|Gene ID (NCBI)||9444|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
QKI belongs to a family of RNA-binding proteins, which have an HNRNPK homology (KH) domain embedded in a 200-amino acid region called the GSG domain. It involves in regulation of RNA splicing, export of target RNAs from the nucleus, translation of proteins, and RNA stability. Also it required to protect and promote stability of mRNAs such as MBP and CDKN1B. Beside, it acts as a regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia.
Clin Exp Pharmacol Physiol
LncRNA PTCSC3 inhibits the proliferation, invasion and migration of cervical cancer cells via sponging miR-574-5p.
Naunyn Schmiedebergs Arch Pharmacol
Inhibition of miR-574-5p suppresses cell growth and metastasis and enhances chemosensitivity by targeting RNA binding protein QKI in cervical cancer cells.
MiR-362-5p, Which Is Regulated by Long Non-Coding RNA MBNL1-AS1, Promotes the Cell Proliferation and Tumor Growth of Bladder Cancer by Targeting QKI.
J Cell Physiol
Quaking promotes the odontoblastic differentiation of human dental pulp stem cells.
J Biol Chem
RNA binding protein Quaking stabilizes Sirt2 mRNA during oligodendroglial differentiation.
J Biol Chem
MicroRNA-214 Promotes Dendritic Development by Targeting the Schizophrenia-associated Gene Quaking.