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QKI Antibody 5 Publications

Rabbit Polyclonal| Catalog number: 13169-1-AP

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Con: 20 μg/150 μl

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Tested Applications

Applications:
WB, IP, IHC, IF, ELISA
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QKI Antibody WB K-562 cells 13169-1-AP

K-562 cells were subjected to SDS PAGE followed by western blot with 13169-1-AP(QKI antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours

QKI Antibody IP K-562 cells 13169-1-AP

IP Result of anti-QKI (IP:13169-1-AP, 4ug; Detection:13169-1-AP 1:400) with K-562 cells lysate 3600ug.

Species specificity:
human, mouse, rat
Positive WB detected in:
K-562 cells
Positive IP detected in:
K-562 cells
Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
Sample-dependent, check data in Validation tab

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
QKI fusion protein Ag3822
Full name:
quaking homolog, KH domain RNA binding (mouse)
Calculated molecular weight:
341aa,38 kDa
Observed molecular weight:
38 kDa
GenBank accession number:
BC019917
Gene ID (NCBI):
9444
Gene symbol
QKI
Synonyms
HKQ, Hqk, HqkI, Protein quaking, QK, QK1, QK3, QKI

Background

QKI belongs to a family of RNA-binding proteins, which have an HNRNPK homology (KH) domain embedded in a 200-amino acid region called the GSG domain. It involves in regulation of RNA splicing, export of target RNAs from the nucleus, translation of proteins, and RNA stability. Also it required to protect and promote stability of mRNAs such as MBP and CDKN1B. Beside, it acts as a regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia.


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