RRM1 Antibody 34 Publications

Rabbit Polyclonal| Catalog number: 10526-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 33 μg/150 μl

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Species specificity:
human, mouse, rat, monkey, Xenopus

Positive WB detected in:
HeLa cells, A549

Positive IP detected in:
K-562 cells

Positive IHC detected in:
human lung cancer tissue

Positive IF detected in:
Hela cells, HepG2 cells, MCF-7 cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:100-1:400
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ribonucleotide reductase M1

Calculated molecular weight:
90 kDa

Observed molecular weight:
90 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
RRM1

Synonyms
R1, ribonucleotide reductase M1, RIR1, RR1, RRM1
Background

Ribonucleoside-diphosphate reductase functions as a heterodimer of a large and a small subunits in deoxyribonucleotide synthesis. RRM1 constitutes to the large subunit (R1) of ribonucleotide reductase, and it can either form heterodimer with small subunit RRM or RRM2B(PMID:16376858). RRM1 provides the precursors necessary for DNA synthesis. RRM1 can not be detected in quiescent cells, while its mRNA and protein are present throughout the cell cycle in cycling cells(PMID:8188248). Researches showed that RRM1 is involved in carcinogenesis, tumor progression, and the resistance of non-small-cell lung cancer (NSCLC) to treatment. Low level expression of RRM1 in NSCLC is associated with poor survival(PMID:17314339).


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