PAI-1 Antibody 6 Publications

Rabbit Polyclonal| Catalog number: 13801-1-AP

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Freight/Packing

Con: 36 μg/150 μl

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Species specificity:
human, rat, mouse

Positive WB detected in:
PC-12 cells,mouse lung tissue, HepG2 cells

Positive IP detected in:
SH-SY5Y cells

Positive IHC detected in:
human lung cancer tissue, human lung cancer tissue, human pancreas cancer tissue

Positive IF detected in:
SH-SY5Y cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

Calculated molecular weight:
402aa,45 kDa

Observed molecular weight:
45 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SERPINE1

Synonyms
PAI, PAI 1, PAI1, PAI-1, PLANH1, Serpin E1, SERPINE1, PAI-1
Background

SERPINE1, also named as Plasminogen activator inhibitor type 1 (PAI-1), is a member of the serine protease inhibitor (SERPIN) superfamily. PAI-1 is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. In western blotting, we got two bands 50 kDa and 90-110 kDa, and 90-110 kDa consistent with PAI-1 in complex with its target protease, t-PA (PMID: 21596853).


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