|Positive IHC detected in||human skin cancer tissue, human cervical cancer tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
13639-1-AP targets DSS1 in WB, IHC, IF, ELISA applications and shows reactivity with human samples.
|Host / Isotype||Rabbit / IgG|
|Immunogen||DSS1 fusion protein Ag4573|
|Full Name||split hand/foot malformation (ectrodactyly) type 1|
|Calculated molecular weight||70 aa, 8 kDa|
|GenBank accession number||BC032782|
|Gene ID (NCBI)||7979|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
DSS1 promoter hypomethylation and overexpression predict poor prognosis in melanoma and squamous cell carcinoma patients.
DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells.
Breast cancers with high DSS1 expression that potentially maintains BRCA2 stability have poor prognosis in the relapse-free survival.
J Med Genet
Absent expression of the osteoblast-specific maternally imprinted genes, DLX5 and DLX6, causes split hand/split foot malformation type I.
The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response.
BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.