SREBF1 Antibody 18 Publications

Rabbit Polyclonal| Catalog number: 14088-1-AP

Featured Product KD/KO validated

  • Print page
  • Download PDF

-_-

Freight/Packing

Con: 81 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, chicken, rat

Positive WB detected in:
HeLa cells, L02 cells

Positive IP detected in:
L02 cells

Positive IHC detected in:
human kidney tissue, human skeletal muscle tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
sterol regulatory element binding transcription factor 1

Calculated molecular weight:
1177aa,125 kDa

Observed molecular weight:
125 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SREBF1

Synonyms
bHLHd1, SREBF1, SREBP 1, SREBP 1c, SREBP1
Background

SREBF1, also named as BHLHD1 and SREBP1, contains one basic helix-loop-helix (bHLH) domain and belongs to the SREBP family. It is a transcriptional activator required for lipid homeostasis. The SREBPs are synthesized as precursors anchored to endoplasmic reticulum (ER) membranes and complexed with SCAP. When the cellular cholesterol level is low, SREBP-SCAP complexes move to the Golgi apparatus, where SREBPs undergo a two-step proteolytic processing, leading to the release of the mature form, an N-terminal fragment, i.e, basic helix-loop-helix leucine zipper transcription factor. These factors enter the nucleus where they bind to sterol regulatory elements (SRE) in the promoter regions of a number of genes whose products mediate the synthesis of cholesterol and fatty acids. [PMID: 21698267]. This antibody can recognize the 125kd precursor form and the 68kd mature form of human SREBF1.


Back
to top