STAT5A Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66459-1-Ig |CloneNo.: 1F10F6

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Freight/Packing

Con: 150 μg/150 μl

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Species specificity:
human, mouse, pig, rat

Positive WB detected in:
RAW 264.7 cells, U-937 cells

Recommended dilution:
WB : 1:2000-1:16000

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2a

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
signal transducer and activator of transcription 5A

Calculated molecular weight:
794aa,92 kDa

Observed molecular weight:
95 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
STAT5A

Synonyms
MGF, STAT5, STAT5A
Background

STAT5A, also named as STAT5, belongs to the transcription factor STAT family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5A is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of STAT5A in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of human STAT5A is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of STAT5A in cells.


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