Thyroglobulin Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 21714-1-AP

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Freight/Packing

Con: 40 μg/150 μl

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Species specificity:
human

Positive WB detected in:
Transfected HEK-293 cells

Positive IHC detected in:
human thyroid tissue, human thyroid tissue, human thyroid cancer tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
thyroglobulin

Calculated molecular weight:
2768aa,305 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TG

Synonyms
AITD3, TG, TGN, thyroglobulin
Background

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.


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