TOM70 Antibody 12 Publications

Rabbit Polyclonal| Catalog number: 14528-1-AP

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Freight/Packing

Con: 39 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse liver tissue, MCF-7 cells, mouse brain tissue, mouse heart tissue, mouse liver mitochondria tissue, mouse skeletal muscle tissue, rat heart tissue, rat skeletal muscle tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human heart tissue, human heart tissue, human kidney tissue, human liver tissue

Positive IF detected in:
HepG2 cells, Hela cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)

Calculated molecular weight:
67 kDa

Observed molecular weight:
67 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TOMM70A

Synonyms
TOM70, TOMM70A
Background

TOMM70A (or TOM70) is a mitochondrial import receptor responsible for the import of cytosol synthesized precursor proteins into the mitochondria. Tom70 is a member of the tetratricopeptide repeat (TPR) co-chaperone family and contains a conserved TPR clamp domain for interaction with Hsc70 and Hsp90. Recently overexpression of TOM70 has been linked to chemoresistance to drugs in breast cancer cell lines. It is also believed that Tom70 is significantly associated with breast cancer relapse and may predict the recurrence of ovarian cancer.


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