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  • KD/KO Validated

Hamartin/TSC1 Polyclonal antibody

Hamartin Polyclonal Antibody for IF, WB,ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat





Cat no : 20988-1-AP


Hamartin, KIAA0243, LAM, TSC, TSC1, tuberous sclerosis 1, Tuberous sclerosis 1 protein

Tested Applications

Positive WB detected inHeLa cells
Positive IF detected inHeLa cells

Recommended dilution

Western Blot (WB)WB : 1:500-1:2000
Immunofluorescence (IF)IF : 1:10-1:100
Sample-dependent, check data in validation data gallery

Product Information

20988-1-AP targets Hamartin in WB, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name tuberous sclerosis 1
Calculated molecular weight 130 kDa
Observed molecular weight
GenBank accession numberNM_000368
Gene symbol TSC1
Gene ID (NCBI) 7248
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

TSC1, also named as KIAA0243 and TSC, is implicated as a tumor suppressor. It is involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. In complex with TSC2, TSC1 inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. It seems not to be required for TSC2 GAP activity towards RHEB. It is involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Defects in TSC1 are the cause of tuberous sclerosis complex (TSC). Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC). The antibody is specific to TSC1. This antibody can recognize two isoforms: 70 kDa (667aa) and 130 kDa.


Product Specific Protocols
IHC protocol for Hamartin antibody 20988-1-APDownload protocol
IF protocol for Hamartin antibody 20988-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Physiol Rep

Tuberous sclerosis complex exhibits a new renal cystogenic mechanism.

Authors - John J Bissler

Wound Repair Regen

Activation of mTORC1 in fibroblasts accelerates wound healing and induces fibrosis in mice.

Authors - Xiao Hu
  • KD Validated

Biochem Biophys Res Commun

UBE2S exerts oncogenic activities in urinary bladder cancer by ubiquitinating TSC1.

Authors - Hao Tang
  • KD Validated


mTORC1 promotes mineralization via p53 pathway.

Authors - Xinghong Luo

Sci Rep

Tsc1 deficiency impairs mammary development in mice by suppression of AKT, nuclear ERα, and cell-cycle-driving proteins.

Authors - Zhenqi Qin
  • KO Validated

Mol Ther Nucleic Acids

miR-301a Suppression within Fibroblasts Limits the Progression of Fibrosis through the TSC1/mTOR Pathway.

Authors - Jiexuan Wang
  • KD Validated