phospho(403/404)-TDP43 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 22310-1-AP

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Freight/Packing

Con: 35 μg/150 μl

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Tested Applications

Applications:
ELISA
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Species specificity:
human

Recommended dilution:

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
TAR DNA binding protein

Calculated molecular weight:
43 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TARDBP

Synonyms
ALS10, TAR DNA binding protein, TAR DNA binding protein 43, TARDBP, TDP 43, TDP43
Background

Transactivation response (TAR) DNA-binding protein of 43 kDa (also known as TARDBP or TDP-43) was first isolated as a transcriptional inactivator binding to the TAR DNA element of the HIV-1 virus. Neumann et al. (2006) found that a hyperphosphorylated, ubiquitinated, and cleaved form of TARDBP, known as pathologic TDP-43, is the major component of the tau-negative and ubiquitin-positive inclusions that characterize amyotrophic lateral sclerosis (ALS) and the most common pathological subtype of frontotemporal lobar degeneration (FTLD-U).10782-2-AP is a rabbit polyclonal antibody recognizing the cleavage product of 20-30 kDa in addition to the native and phosphorylated forms of TDP-43. Immunohistochemical analyses of TDP-43 using this antibody detect both normal diffuse nuclear staining and insoluble inclusions in pathologic tissues. A variety of TDP-43-positive pathological inclusions have been found in FTLD-U (now referred to as FTLD-TDP), including neuronal cytoplasmic inclusions (NCIs), dystrophic neurites (DNs), neuronal intra-nuclear inclusions (NIIs), and glial cytoplasmic inclusions (GCIs).


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