Recombinant Human Alpha 1B-Glycoprotein protein (His Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
His Tag
Activity
not tested
Cat no : Eg1511
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human Alpha 1B-Glycoprotein protein Ala22-Ser495 (Accession# P04217-1) with a His tag at the C-terminus. |
| GeneID | 1 |
| Accession | P04217-1 |
| PredictedSize | 53.0 kDa |
| SDS-PAGE | 58-70 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
A1BG, which stands for Alpha-1B-Glycoprotein, is a glycoprotein primarily synthesized by the liver and secreted into the bloodstream. It is an important component of plasma proteins, but its precise physiological function has long remained unclear, earning it the designation of an "orphan" plasma protein. Current research indicates that as a secretory protein, A1BG undergoes significant changes in serum concentration under various disease conditions. Particularly in multiple cancers (such as liver cancer and ovarian cancer), autoimmune diseases, and inflammatory responses, it demonstrates considerable potential as a diagnostic and prognostic biomarker. Although its molecular mechanisms have not yet been fully elucidated, it is hypothesized to be involved in processes such as immune regulation and protease inhibition.
References:
1. Han, Xiuxin et al. Expert opinion on therapeutic targets vol. 27,10 (2023): 1017-1029. 2. El Atab, Ola et al. The Journal of biological chemistry vol. 300,12 (2024): 107910. 3. Wang, Jian et al. Scientific reports vol. 13,1 20730. 25 Nov. 2023. 4. Liang, Yonghui et al. Advanced science (Weinheim, Baden-Wurttemberg, Germany) vol. 12,35 (2025): e02926.