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Recombinant Human KLRG1 protein (rFc Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg2036

Validation Data Gallery

  • Purity of Recombinant Human KLRG1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human KLRG1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human KLRG1 protein Leu60-Phe195 (Accession# Q96E93-1) with a rabbit IgG Fc tag at the N-terminus.
GeneID 10219
Accession Q96E93-1
PredictedSize 42.7 kDa
SDS-PAGE 45-65 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

KLRG1 (killer cell lectin-like receptor subfamily G, member 1) is a C-type lectin inhibitory receptor that contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain. KLRG1 is expressed by subsets of NK and T cells, existing both as a monomer and as a disulfide-linked homodimer. It is considered to be a cell differentiation marker for NK and T cells and is strongly induced by viral and other infections. Through interactions with members of the cadherin family, KLRG1 plays an inhibitory role on NK- and T-cell function.

References:

1. L Corral, et al. (2000) Eur J Immunol. Mar;30(3):920-30.
2. Yili Li, et al. (2009) Immunity. Jul 17;31(1):35-46.
3. Stipan Jonjic. (2010) Eur J Immunol. May;40(5):1241-3.
4. Stephan Rosshart, et al. (2008) Eur J Immunol. Dec;38(12):3354-64.