Recombinant Mouse Il2rb protein (rFc Tag)
Species
Mouse
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg2709
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <1.0 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Mouse Il2rb protein Ala27-Glu240 (Accession# P16297) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 16185 |
| Accession | P16297 |
| PredictedSize | 50.6 kDa |
| SDS-PAGE | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
IL-2RB (CD122) is a 70-75 kD type I transmembrane glycoprotein and a member of the immunoglobulin superfamily, also known as the IL-2 receptor beta chain. It is a critical component of the IL-2 receptor complex, which exists in three forms with varying affinities for IL-2: low (alpha subunit only), intermediate (alpha/beta heterodimer), and high (alpha/beta/gamma heterotrimer) affinity forms. IL-2RB is involved in receptor-mediated endocytosis and transduces mitogenic signals from IL-2, playing a key role in T cell-mediated immune responses. It is also shared by the IL-15 receptor and is essential for the development and function of regulatory T cells. IL-2RB expression is restricted to early B cells and activated T and B lymphocytes, highlighting its importance in lymphocyte development and activation.
References:
1. de Jong, J L et al. Cytokine vol. 10,12 (1998): 920-30. 2. Ruyssen-Witrand, Adeline et al. Joint bone spine vol. 81,3 (2014): 228-34. 3. He, Lingge et al. Biochemical genetics vol. 59,3 (2021): 697-713. 4. Sun, Lina et al. Signal transduction and targeted therapy vol. 9,1 (2024): 152.