Recombinant Mouse ICAM5 protein (rFc Tag)
Species
Mouse
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg2868
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Mouse ICAM5 protein Glu32-Pro832 (Accession# Q60625) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 15898 |
| Accession | Q60625 |
| PredictedSize | 111.4 kDa |
| SDS-PAGE | 130-160 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
ICAM-5, also known as telencephalin, is a type I integral membrane glycoprotein of the immunoglobulin superfamily. It is specifically expressed in the postnatal excitatory neuronal cell bodies, dendritic shafts, and dendritic filopodia of the telencephalon. ICAM-5 functions in both the immune and nervous systems. ICAM-5 strongly stimulates neurite outgrowth. It is cleaved by matrix metalloproteases upon activation of glutamate receptors or degraded through endocytosis resulting in increased spine maturation. The cleaved soluble fragment of ICAM-5 is immunosuppressive, which may be important in neuronal inflammatory diseases.
References:
1. Arii, N et al. Microscopy research and technique vol. 46,1 (1999): 18-23. 2. Tian, Li et al. The Journal of cell biology vol. 178,4 (2007): 687-700. 3. Gahmberg, Carl G et al. Advances in neurobiology vol. 8 (2014): 117-32.