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Recombinant Rat NCAM-1/CD56 protein (rFc Tag)(HPLC verified)

Species

Rat

Purity

>90 %, SDS-PAGE
>90%, SEC-HPLC

Tag

rFc Tag

Activity

not tested

Cat no : Eg3243

Validation Data Gallery

  • Purity of Recombinant Rat NCAM-1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Rat NCAM-1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Rat NCAM-1/CD56 was greater than 90% as determined by SEC-HPLC.

    The purity of Rat NCAM-1/CD56 was greater than 90% as determined by SEC-HPLC.

Product Information

Purity >90 %, SDS-PAGE
>90%, SEC-HPLC
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Rat NCAM-1 protein Leu20-Thr721 (Accession# P13596-1) with a rabbit IgG Fc tag at the C-terminus.
GeneID 24586
Accession P13596-1
PredictedSize 104.0 kDa
SDS-PAGE 120-130 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

NCAM-1 (Neural Cell Adhesion Molecule 1), also known as CD56, is a cell-surface glycoprotein that is a member of the immunoglobulin superfamily and expresses three isoforms at 120, 140, and 180 kDa. NCAM-1 plays a role in cell development and differentiation as well as in immune surveillance, and is involved in the regulation of cellular adhesion and survival, intracellular signaling, cytoskeletal dynamics, neurological development, synaptic plasticity, learning and memory, and immune surveillance. It plays a role in signal transduction by interacting with fibroblast growth factor receptor, N-calmodulin and activating the signaling cascade of FAK, MAPK, and PI3K.Abnormal NCAM-1 expression is seen in a range of hematological malignancies including multiple myeloma and leukemias, and solid tumors, such as lung cancer, ovarian cancer, and neuroblastoma.

References:

1. Chu CS, et al. (2018) Psychiatry Investig.15(7):727-732.                                            
2. Sasca D, et al. (2019) Blood. 133(21):2305-2319.
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