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Recombinant Human KIR2DS4 protein (rFc Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg4353

Validation Data Gallery

  • Purity of Recombinant Human KIR2DS4 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human KIR2DS4 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human KIR2DS4 protein Gln22-His245 (Accession# P43632) with a rabbit IgG Fc tag at the C-terminus.
GeneID 3809
Accession P43632
PredictedSize 50.7 kDa
SDS-PAGE 62-85 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

KIR2DS4 is a member of the killer cell immunoglobulin-like receptor (KIR) family, which plays a critical role in the immune system, particularly in the function of natural killer (NK) cells. It is expressed on the cell surface, primarily in NK cells, which function as a receptor for HLA class I molecules. This protein has been linked to susceptibility to certain bacterial infections by detecting a conserved bacterial epitope presented by HLA-C. It also has been associated with basaloid tumors, lymph node metastasis, advanced stage, and metastatic risk in head and neck squamous cell carcinoma.

References:

1.Merino AM. et al. (2014). PLoS One. 9(6):e99353.
2.Sim MJW. et al. (2019). Proc Natl Acad Sci U S A. 116(26):12964-12973.
3.Barani S. et al. (2020). Exp Mol Pathol. 112:104345.