ADAM12 Antibody 17 Publications

Rabbit Polyclonal| Catalog number: 14139-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 39 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse brain tissue,HeLa cells, mouse heart tissue, mouse colon tissue, Y79 cells, human placenta tissue

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human breast cancer tissue,human placenta tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ADAM metallopeptidase domain 12

Calculated molecular weight:
100 kDa

Observed molecular weight:
97 kDa,68 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ADAM12

Synonyms
ADAM 12, ADAM12, MCMP, MCMPMltna, Meltrin alpha, MLTN, MLTNA
Background

ADAM12, also named as MLTN and Meltrin-alpha, is involved in skeletal muscle regeneration, specifically at the onset of cell fusion. It is also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors. ADAM12 is expressed in human malignant tumors. It is involved in the regulation of growth factor activities and integrin functions, leading to promotion of cell growth and invasion, although the precise mechanisms of these are not clear at the present time.(PMID:17355265) ADAM12’s ability to degrade extracellular matrix components likely allows it to detach cancer cells from the basement membrane and assist them on their route to metastasis. But the protein’s role not just as a biomarker of breast cancer but as a gateway to cancer cell migration is only now being understood. This antibody can recognize all isoforms of ADAM12. ADAM12 has 4 forms: 120kd full-length form, 90kd mature(processed form that lack the prodomain);50-68kd degradation product and 27kd prodomain.


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