APLP2 Polyclonal antibody

APLP2 Polyclonal Antibody for WB, IP, IHC, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat





Cat no : 15041-1-AP


Amyloid like protein 2, Amyloid protein homolog, APLP 2, APLP2, APPH, APPL2, CDEBP, CDEI box binding protein

Tested Applications

Positive WB detected inHEK-293 cells, mouse brain tissue, rat brain tissue
Positive IP detected inmouse brain tissue
Positive IHC detected inhuman brain tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

Western Blot (WB)WB : 1:500-1:1000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
Immunohistochemistry (IHC)IHC : 1:20-1:200
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Published Applications

WBSee 2 publications below

Product Information

15041-1-AP targets APLP2 in WB, IP, PLA, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen APLP2 fusion protein Ag6838
Full Name amyloid beta (A4) precursor-like protein 2
Calculated Molecular Weight 87 kDa
Observed Molecular Weight 120 kDa
GenBank Accession NumberBC000373
Gene Symbol APLP2
Gene ID (NCBI) 334
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Amyloid precursor-like protein-2 (APLP2) is a member of the APP (amyloid precursor protein) family including APP, APLP1, and APLP2. APLP2 is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. APLP2 has been shown to regulate multiple cellular functions such as neurite outgrowth, axogenesis, corneal epithelial wound healing, cell adhesion, migration, and mitosis. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. APLP2 has been implicated in the pathogenesis of Alzheimer's disease.


Product Specific Protocols
WB protocol for APLP2 antibody 15041-1-APDownload protocol
IHC protocol for APLP2 antibody 15041-1-APDownload protocol
IP protocol for APLP2 antibody 15041-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols




Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia

Authors - Yu-Han H Hsu

Life Sci Alliance

Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling.

Authors - Jennifer J Schwarz


HMGA2 overexpression activates IGF2BP2 to stabilize APLP2 via m6A modification and promote pancreatic cancer progression

Authors - Ke Liu