ARL13B Antibody 145 Publications

Rabbit Polyclonal| Catalog number: 17711-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 41 μg/150 μl

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Species specificity:
human, mouse, rat, dog, pig, sheep, Xenopus, Zebrafish

Positive WB detected in:
mouse liver tissue,Transfected HEK-293 cells, L02 cells, mouse kidney tissue, mouse brain tissue, NIH/3T3 cells

Positive IP detected in:
L02 cells

Positive IHC detected in:
mouse brain tissue,human testis tissue, human liver tissue, human kidney tissue

Positive IF detected in:
MDCK cells,hTERT-RPE1 , mouse embryonic fibroblasts , NIH3T3 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:300
IF : 1:50-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ADP-ribosylation factor-like 13B

Calculated molecular weight:
321aa,37 kDa

Observed molecular weight:
40-48 kDa, 66 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ARL13B

Synonyms
ARL13B, ARL2 like protein 1, ARL2L1, DKFZp686E2075, DKFZp686L2472, DKFZp686M2074, DKFZp761H079, JBTS8
Background

ARL13B, also named as ARL2L1, is a small ciliary G protein of the Ras superfamily. Localized in the cilia, it is required for cilium biogenesis and sonic hedgehog signaling. Defects in ARL13B are the cause of Joubert syndrome (JS) which is an autosomal recessive disorder characterized by a distinctive cerebellar malformation (PMID: 19906870).This antibody detects two specific bands at 60 kDa and 48 kDa. Arl13b is predicted to be a 48 kDa protein, and the 60 kDa band is likely to represent a modified form of Arl13b. ARL13B can be used to mark the cilia (PMID:22072986).


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