Product Information
19513-1-AP targets ASAH2-Specific in ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide Predict reactive species |
| Full Name | N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 |
| Calculated Molecular Weight | 86 kDa |
| GenBank Accession Number | NM_019893 |
| Gene Symbol | ASAH2 |
| Gene ID (NCBI) | 56624 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9NR71 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
ASAH2, also named as HNAC1, belongs to the neutral ceramidase family. ASAH2 catalyze the reaction: N-acylsphingosine + H2O = a carboxylate + sphingosine. ASAH2 hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. ASAH2 acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. And ASAH2 acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. ASAH2 is probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract.
