• Featured Product
  • KD/KO Validated

cIAP1 Polyclonal antibody

cIAP1 Polyclonal Antibody for IF, IHC, WB, ELISA

Host / Isotype

Rabbit / IgG


human, mouse and More (1)





Cat no : 10022-1-AP


API1, BIRC2, C IAP1, cIAP1, Hiap 2, HIAP2, IAP 2, IAP homolog B, IAP2, MIHB, RING finger protein 48, RNF48

Tested Applications

Positive WB detected inmouse skeletal muscle tissue, Jurkat cells, mouse brain tissue, mouse liver tissue, mouse testis tissue
Positive IHC detected inhuman testis tissue, mouse pancreas tissue, mouse testis tissue, human pancreas tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inHepG2 cells

Recommended dilution

Western Blot (WB)WB : 1:500-1:2000
Immunohistochemistry (IHC)IHC : 1:50-1:500
Immunofluorescence (IF)IF : 1:200-1:800
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Product Information

10022-1-AP targets cIAP1 in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman, mouse, zebrafish
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen cIAP1 fusion protein Ag15203
Full Name baculoviral IAP repeat-containing 2
Calculated molecular weight 618 aa, 70 kDa
Observed molecular weight 70 kDa, 55-60 kDa
GenBank accession numberBC016174
Gene symbol BIRC2
Gene ID (NCBI) 329
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

BIRC2 (also known as cIAP1) is a member of the inhibitor of apoptosis protein (IAP) family. The inhibitor of apoptosis (IAP) proteins are a family of anti-apoptotic regulators found in viruses and metazoans. BIRC2 is a nuclear shuttling protein, whose subcellular localization is mediated by the CRM1-dependent nuclear export pathway (PMID: 15265700). The protein is regulated transcriptionally and can be inhibited by mitochondrial proteins released in the cytoplasm upon apoptotic stimuli (PMID: 15187025). BIRC2 is also believed to be a critical regulator of vascular integrity and endothelial cell survival, thereby providing an additional target pathway for the control of angiogenesis and blood vessel homeostasis during embryogenesis, regeneration and tumorigenesis (PMID: 17934460). This BIRC2 antibody (10022-1-AP) can bind both full length (70kd) and cleaved form (60kd) of the protein.


Product Specific Protocols
WB protocol for cIAP1 antibody 10022-1-APDownload protocol
IHC protocol for cIAP1 antibody 10022-1-APDownload protocol
IF protocol for cIAP1 antibody 10022-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Nat Genet

Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis.

Authors - Santoro Massimo M MM
  • KD Validated

Mol Cell

Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB.

Authors - Mingjian Du

Mol Cell

A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation.

Authors - Michael Hinz
  • KD Validated

Acta Pharm Sin B

A new perspective of triptolide-associated hepatotoxicity: the relevance of NF- κ B and NF- κ B-mediated cellular FLICE-inhibitory protein.

Authors - Ziqiao Yuan

Dev Cell

Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform.

Authors - Maria Zachari

J Immunol

Differential TRAF3 utilization by a variant human CD40 receptor with enhanced signaling.

Authors - Peters Anna L AL