NeutraKine™ BMP-7 Monoclonal antibody

NeutraKine™ BMP-7 Monoclonal Antibody for FC, Neutralization,ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

Neutralization, FC,ELISA

Conjugate

Unconjugated

CloneNo.

3E9G7

Cat no : 69011-1-Ig

Synonyms

BMP 7, BMP7, BMP-7, bone morphogenetic protein 7, Eptotermin alfa, OP 1, OP1, Osteogenic protein 1



Tested Applications

Planning an IF experiment? We recommend our CoraLite®647 conjugated versions of this antibody.
Neutralization

Product Information

69011-1-Ig targets NeutraKine™ BMP-7 in Neutralization, FC,ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen human Humankine BMP-7 protein HZ-1229
Full Name bone morphogenetic protein 7
Gene symbol BMP7
Gene ID (NCBI) 655
Conjugate Unconjugated
Form Lyophilized Powder
Purification Method Protein G purification
Storage Buffer Sterile PBS.
Endotoxin<0.1 EU/μg
ReconstitutionThis product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
Stability and StorageLyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

Background Information

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site.

BMP7, also known as osteogenic protein-1 or OP-1, plays a key role in the transformation of mesenchymal cells into bone and cartilage. BMP7 may be involved in bone homeostasis (PMID: 15621726). It is expressed in the brain, kidneys and bladder. BMP7 is also present in cancers, including breast, prostate, and colon cancers, in which it is implicated in regulating cancer cell proliferation (PMID: 16419056, PMID: 15531927). Overexpression of BMP7 mRNA in colorectal cancer patients was significantly associated with poor prognosis and low overall survival (PMID: 18259822). Recent studies suggest that high-expression level of BMP7 serves as a biomarker for poor prognosis for HCC (PMID: 23179403).

This antibody is used to Block/Neutralize BMP-7 protein.

Protocols

Product Specific Protocols
Neutralization protocol of NeutraKine™ BMP-7 antibody 69011-1-IgDownload protocol
FC protocol for NeutraKine™ BMP-7 antibody 69011-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols