C1qA Polyclonal antibody
C1qA Polyclonal Antibody for IP, WB, ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse, rat
Applications
WB, IP, IF, ELISA
Conjugate
Unconjugated
Cat no : 11602-1-AP
Synonyms
Validation Data Gallery
Tested Applications
Positive WB detected in | human spleen tissue, human colon tissue, human heart tissue, human liver tissue, human lung tissue, mouse liver tissue, mouse serum tissue |
Positive IP detected in | mouse liver tissue |
Recommended dilution
Application | Dilution |
---|---|
Western Blot (WB) | WB : 1:500-1:2000 |
Immunoprecipitation (IP) | IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB |
Sample-dependent, check data in validation data gallery |
Published Applications
WB | See 6 publications below |
IF | See 2 publications below |
Product Information
11602-1-AP targets C1qA in WB, IP, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Reactivity | human, mouse, rat |
Cited Reactivity | human, mouse, rat |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | C1qA fusion protein Ag2141 |
Full Name | complement component 1, q subcomponent, A chain |
Calculated molecular weight | 245 aa, 26 kDa |
Observed molecular weight | 30 kDa |
GenBank accession number | BC030153 |
Gene symbol | C1QA |
Gene ID (NCBI) | 712 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
The first component of complement, C1, is a calcium-dependent complex of the 3 subcomponents C1q, C1r, and C1s. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. This antibody is raised against C1qA which is the A-chain polypeptide of human complement subcomponent C1q.
Protocols
Product Specific Protocols | |
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WB protocol for C1qA antibody 11602-1-AP | Download protocol |
IP protocol for C1qA antibody 11602-1-AP | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |
Publications
Species | Application | Title |
---|---|---|
Cell Mol Life Sci Dietary intake of α-ketoglutarate ameliorates α-synuclein pathology in mouse models of Parkinson's disease | ||
Neurochem Res Blocking Two-Pore Domain Potassium Channel TREK-1 Inhibits the Activation of A1-Like Reactive Astrocyte Through the NF-κB Signaling Pathway in a Rat Model of Major Depressive Disorder | ||
J Mol Cell Cardiol Cellular heterogeneity and immune microenvironment revealed by single-cell transcriptome in venous malformation and cavernous venous malformation. | ||
Sci Rep C-reactive protein (CRP) recognizes uric acid crystals and recruits proteases C1 and MASP1. | ||
Oncol Lett Role of uromodulin and complement activation in the progression of kidney disease. |