Validation Data Gallery
|Positive WB detected in||human spleen tissue, human colon tissue, human heart tissue, human liver tissue, human lung tissue, mouse liver tissue, mouse serum tissue|
|Positive IP detected in||mouse liver tissue|
|Western Blot (WB)||WB : 1:500-1:2000|
|Immunoprecipitation (IP)||IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB|
|Sample-dependent, check data in validation data gallery|
11602-1-AP targets C1qA in WB, IP, IF applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||C1qA fusion protein Ag2141|
|Full Name||complement component 1, q subcomponent, A chain|
|Calculated molecular weight||245 aa, 26 kDa|
|Observed molecular weight||30 kDa|
|GenBank accession number||BC030153|
|Gene ID (NCBI)||712|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
The first component of complement, C1, is a calcium-dependent complex of the 3 subcomponents C1q, C1r, and C1s. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. This antibody is raised against C1qA which is the A-chain polypeptide of human complement subcomponent C1q.
Role of uromodulin and complement activation in the progression of kidney disease.
C-reactive protein (CRP) recognizes uric acid crystals and recruits proteases C1 and MASP1.
J Mol Cell Cardiol
Cellular heterogeneity and immune microenvironment revealed by single-cell transcriptome in venous malformation and cavernous venous malformation.
Immune quiescence of the brain is set by astroglial connexin 43.