CACNA1B Polyclonal antibody

CACNA1B Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat





Cat no : 19681-1-AP


BIII, Brain calcium channel III, CACH5, CACNA1B, CACNL1A5, CACNN, Cav2.2

Tested Applications

Positive IHC detected inmouse brain tissue, mouse cerebellum tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

19681-1-AP targets CACNA1B in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name calcium channel, voltage-dependent, N type, alpha 1B subunit
Calculated Molecular Weight 262 kDa
GenBank Accession NumberNM_000718
Gene Symbol CACNA1B
Gene ID (NCBI) 774
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

CACNA1B, also named as CACH5, CACNL1A5 and BIII, belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. CACNA1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). CACNA1B may play a role in directed migration of immature neurons.


Product Specific Protocols
IHC protocol for CACNA1B antibody 19681-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Mol Neurobiol

Genomic Action of Sigma-1 Receptor Chaperone Relates to Neuropathic Pain.

Authors - Shao-Ming Wang

Front Pharmacol

Sigma-1 Receptor Plays a Negative Modulation on N-type Calcium Channel.

Authors - Kang Zhang

J Recept Signal Transduct Res

CACNA1B facilitates breast cancer cell growth and migration by regulating cyclin D1 and EMT: the implication of CACNA1B in breast cancer.

Authors - Yong-Mei Jin

Cell Death Dis

Cav2.2-NFAT2-USP43 axis promotes invadopodia formation and breast cancer metastasis through cortactin stabilization

Authors - Ying Xue
  • KO Validated