- Featured Product
- KD/KO Validated
Calsequestrin 2 Polyclonal antibody
Calsequestrin 2 Polyclonal Antibody for IF, IHC, WB, ELISA
Cat no : 18422-1-AP
Validation Data Gallery
|Positive WB detected in
|mouse heart tissue, human heart tissue, human skeletal muscle tissue, pig heart tissue, rat heart tissue
|Positive IHC detected in
|human heart tissue, human kidney tissue, human ovary tissue, human placenta tissue, human skin tissue, human spleen tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in
|Western Blot (WB)
|WB : 1:2000-1:16000
|IHC : 1:50-1:500
|IF : 1:50-1:500
|It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
|Sample-dependent, check data in validation data gallery
18422-1-AP targets Calsequestrin 2 in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat, pig samples.
|human, mouse, rat, pig
|human, mouse, pig
|Host / Isotype
|Rabbit / IgG
|Calsequestrin 2 fusion protein Ag13246
|calsequestrin 2 (cardiac muscle)
|Calculated molecular weight
|Observed molecular weight
|GenBank accession number
|Gene ID (NCBI)
|Antigen affinity purification
|PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
|Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.
Calsequestrin (CASQ) is a Ca2+-binding protein present primarily in junctional sarcoplasmic reticulum of skeletal and cardiac muscle; the cardiac form (CASQ2) is encoded by a separate gene. The primary role of CASQ2 is buffering of the sarcoplasmic reticulum Ca2+ ions, but another role for CASQ2 has emerged recently: CASQ2 regulates the open probability of ryanodine receptor 2 (RyR2). Mutations in CASQ2 cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.
EMBO Mol Med
SK4 K(+) channels are therapeutic targets for the treatment of cardiac arrhythmias.
The Purkinje-myocardial junction is the anatomical origin of ventricular arrhythmia in CPVT.
Viral delivered gene therapy to treat catecholaminergic polymorphic ventricular tachycardia (CPVT2) in mouse models.
Stem Cell Reports
A Human Stem Cell Model of Fabry Disease Implicates LIMP-2 Accumulation in Cardiomyocyte Pathology.
Mol Biol Cell
Fer1l6 Is Essential for the Development of Vertebrate Muscle Tissue in Zebrafish.
Critical role of Znhit1 for postnatal heart function and vacuolar cardiomyopathy.