Eotaxin Polyclonal antibody

Eotaxin Polyclonal Antibody for IHC,ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human and More (2)

Applications

IHC,ELISA

Conjugate

Unconjugated

Cat no : 11786-1-AP

Synonyms

C C motif chemokine 11, CCL11, Eosinophil chemotactic protein, Eotaxin, SCYA11, Small inducible cytokine A11



Tested Applications

Positive IHC detected inhuman lung cancer tissue, human tonsillitis tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:50-1:500
Sample-dependent, check data in validation data gallery

Published Applications

IHCSee 2 publications below

Product Information

11786-1-AP targets Eotaxin in IHC,ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Cited Reactivity mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Eotaxin fusion protein Ag2398
Full Name chemokine (C-C motif) ligand 11
Calculated molecular weight 97 aa, 11 kDa
GenBank accession numberBC017850
Gene symbol CCL11
Gene ID (NCBI) 6356
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

CCL11 also named Eotaxin-1, was initially discovered as an eosinophil-specific chemoattractant. CCL11 plays a central role in both allergic and non-allergic inflammatory reactions by recruiting immune cells such as eosinophils,basophils and Th2 lymphocytes. CCL11 binds to the chemokine receptors CCR2, CCR3 and CCR5, with highest affinity to CCR3. High levels of CCL11 have been described in several chronic inflammatory diseases, such as allergic rhinitis, atopic dermatitis, asthma, gastrointestinal disease and rheumatoid arthritis.

Protocols

Product Specific Protocols
IHC protocol for Eotaxin antibody 11786-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
ratIHC

Am J Rhinol Allergy

Effects of Ursolic Acid on the Expression of Th1-Th2-related Cytokines in a Rat Model of Allergic Rhinitis After PM2.5 Exposure.

Authors - Na Sun
mouseIHC

Am J Physiol Heart Circ Physiol

Pygo1 regulates pathological cardiac hypertrophy via a β-catenin-dependent mechanism.

Authors - Li Lin