|Positive WB detected in||HEK-293 cells, NIH/3T3 cells, U2OS cells, MCF-7 cells, Caco-2 cells|
|Western Blot (WB)||WB : 1:1000-1:5000|
|Sample-dependent, check data in validation data gallery|
67048-1-Ig targets Cyclin D2 in WB, ELISA applications and shows reactivity with Human, mouse samples.
|Tested Reactivity||Human, mouse|
|Cited Reactivity||human, mouse|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Cyclin D2 fusion protein Ag25190|
|Full Name||cyclin D2|
|Calculated molecular weight||32 kDa|
|Observed molecular weight||30 kDa|
|GenBank accession number||BC010958|
|Gene ID (NCBI)||894|
|Purification Method||Protein A purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Aliquoting is unnecessary for -20oC storage.|
CCND2 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. CCND2 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND2 has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. High level expression of CCND2 was observed in ovarian and testicular tumors.
Technol Cancer Res Treat
The Analysis of Differentially Expressed circRNAs Under the Antiproliferative Effect From 5-Fluorouracil on Osteosarcoma Cells.
Cell Death Dis
Long intergenic non-coding RNA 00473 promotes proliferation and migration of gastric cancer via the miR-16-5p/CCND2 axis and by regulating AQP3.
Am J Cancer Res
miR-1297 inhibits osteosarcoma cell proliferation and growth by targeting CCND2