CD11B/Integrin alpha M Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66519-1-Ig |CloneNo.: 1C7C2

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Con: 150 μg/150 μl

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Species specificity:
Human

Positive WB detected in:
THP-1 cells, human bone marrow tissue

Positive IHC detected in:
human tonsillitis tissue

Recommended dilution:
WB : 1:1000-1:4000
IHC : 1:500-1:2000

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2b

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
integrin, alpha M (complement component 3 receptor 3 subunit)

Calculated molecular weight:
93 kDa

Observed molecular weight:
160 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ITGAM

Synonyms
CD11B, CR 3 alpha chain, CR3A, Integrin alpha M, ITGAM, MAC 1, MAC1A, MO1A, Neutrophil adherence receptor, SLEB6
Background

ITGAM, also named as CD11B and CR3A, belongs to the integrin alpha chain family. It is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. ITGAM is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. It is also a receptor for fibrinogen, factor X and ICAM1. ITGAM recognizes P1 and P2 peptides of fibrinogen gamma chain.


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