Anti-Human CD164 Rabbit Recombinant Antibody, PBS Only

• 

  FC experiment of human PBMCs using 98239-1-RR (same clone as 98239-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD164 Rabbit Recombinant Antibody (98239-1-RR, Clone: 241950F3) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with and 0.25 ug CoraLite® Plus 647 Anti-Human CD14. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98239-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98239-1-RR (same clone as 98239-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD164 Rabbit Recombinant Antibody (98239-1-RR, Clone:241950F3) (red), or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98239-1-PBS in a different storage buffer formulation.

CD164 Uni-rAb^® Recombinant Antibody for FC

Cat No. 98239-1-PBS

Clone No.241950F3

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

Multi-glycosylated core protein 24, MUC-24, MGC-24v, MGC-24, 241950F3

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Product Information

98239-1-PBS targets CD164 in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  Recombinant protein

• Full Name: CD164 molecule, sialomucin
• Calculated Molecular Weight: 21kDa
• GenBank Accession Number: NM_006016.6
• Gene Symbol: CD164
• Gene ID (NCBI): 8763
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q04900-1
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Sialomucins are a heterogeneous group of secreted or membrane-associated mucins that appear to play 2 key but opposing roles in vivo: first as cytoprotective or antiadhesive agents, and second as adhesion receptors. CD164 is a type I integral transmembrane sialomucin that functions as an adhesion receptor (PMID: 9680353)(PMID: 17077324). Sialomucin CD164 (MUC-24), also referred to multi-glycosylated core protein 24 (MGC24), is known to function as a receptor that regulates stem cell localization to the bone marrow. CD164 may play a key role in hematopoiesis by facilitating the adhesion of CD34+ cells to the stroma and by negatively regulating CD34+CD38(lo/-) cell proliferation. Important role of CD164 in in prostate cancer metastasis, promoting myogenesis and regulating myoblast migration so far have been revealed (PMID: 9763543)(PMID: 16859559)(PMID: 17077324).