Anti-Mouse CD204 Rabbit Recombinant Antibody, PBS Only

• 

  FC experiment of mouse peritoneal macrophages using 98576-2-RR (same clone as 98576-2-PBS)

  1x10^6 mouse peritoneal macrophages were surface stained with 0.25 ug Anti-Mouse CD204 Rabbit RecAb (98576-2-RR, Clone: 251367F5) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Mouse F4/80. Cells were not fixed. This data was developed using the same antibody clone with 98576-2-PBS in a different storage buffer formulation.

• 

  FC experiment of mouse peritoneal macrophages using 98576-2-RR (same clone as 98576-2-PBS)

  1x10^6 mouse peritoneal macrophages were surface stained with 0.25 ug Anti-Mouse CD204 Rabbit RecAb (98576-2-RR, Clone: 251367F5) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98576-2-PBS in a different storage buffer formulation.

• 

  FC experiment of RAW 264.7 using 98576-2-RR (same clone as 98576-2-PBS)

  1x10^6 RAW 264.7 cells were surface stained with 0.25 ug Anti-Mouse CD204 Rabbit RecAb (98576-2-RR, Clone: 251367F5) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98576-2-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 98576-2-RR

  Biolayer interferometry (BLl) kinetic assays of 98576-2-RR against Mouse CD204 were performed. The affinity constant is below 1 pM.

CD204 Uni-rAb^® Recombinant Antibody for FC

Cat No. 98576-2-PBS

Clone No.251367F5

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

FC

Synonyms

Macrophage acetylated LDL receptor I and II, macrophage scavenger receptor 1, Macrophage scavenger receptor types I and II, Msr1, Scavenger receptor type A

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Product Information

98576-2-PBS targets CD204 in FC applications and shows reactivity with mouse samples.

• Tested Reactivity: mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Eg4727

  Product name: Recombinant Mouse MSR1 protein (rFc Tag)

  Source: mammalian cells-derived, pHZ-KIsec-N-rFc

  Tag: N-rFc

  Domain: 79-458 aa of NM_001113326.1

  Sequence: QLLNWEMKNCLVCSLNTSDTSQGPMEKENTSKVEMRFTIIMEHMKDMEERIESISNSKADLIDTERFQNFSMATDQRLNDILLQLNSLISSVQEHGNSLDAISKSLQSLNMTLLDVQLHTETLNVRVRESTAKQQEDISKLEERVYKVSAEVQSVKEEQAHVEQEVKQEVRVLNNITNDLRLKDWEHSQTLKNITFIQGPPGPQGEKGDRGLTGQTGPPGAPGIRGIPGVKGDRGQIGFPGGRGNPGAPGKPGRSGSPGPKGQKGEKGSVGGSTPLKTVRLVGGSGAHEGRVEIFHQGQWGTICDDRWDIRAGQVVCRSLGYQEVLAVHKRAHFGQGTGPIWLNEVMCFGRESSIENCKINQWGVLSCSHSEDAGVTCTS

• Full Name: macrophage scavenger receptor 1
• Calculated Molecular Weight: 50 kDa
• GenBank Accession Number: NM_001113326.1
• Gene Symbol: Msr1
• Gene ID (NCBI): 20288
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P30204-1
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

CD204, also known as MSR1, belongs to the scavenger receptor family, which is mainly expressed on the surface of macrophages. CD204 plays a key inflammatory role in various pathophysiological processes, including atherosclerosis, innate and adaptive immunity, lung and liver disease, and cancer. CD204 binds to a variety of ligands, including modified low-density lipoproteins (LDL) and lipids, and is involved in endocytosis, positive regulation of cholesterol storage, and positive regulation of macrophage-derived foam cell differentiation. Studies have shown that CD204 is significantly increased in peripheral blood mononuclear cells (PBMCs) from patients with asthma and chronic obstructive pulmonary disease (COPD), which may serve as a disease marker.