CD40L; CD154 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66502-1-Ig |CloneNo.: 1E6D10

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Freight/Packing

Con: 150 μg/150 μl

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Species specificity:
Human

Positive WB detected in:
Jurkat cells

Positive IHC detected in:
human tonsillitis tissue

Recommended dilution:
WB : 1:1000-1:6000
IHC : 1:200-1:800

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2a

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
CD40 ligand

Calculated molecular weight:
261aa,29 kDa

Observed molecular weight:
32 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CD40LG

Synonyms
CD154, CD40 L, CD40 ligand, CD40L, CD40LG, gp39, hCD40L, HIGM1, IGM, IMD3, T BAM, T cell antigen Gp39, TNF related activation protein, TNFSF5, TRAP
Background

The CD40 ligand (CD40L, TRAP, CD154), a member of the TNF superfamily of ligands, is expressed as either a 33-kd transmembrane homologue or 18-kd soluble form (sCD154). CD40L is primarily expressed on activated CD4+ T cells and on a small proportion of CD8+ T cells and platelets. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. Recent studies have suggested that CD40/CD40L interactions regulate oxidative stress and affect various signaling pathways in both the immunological and the cardiovascular systems. The CD40/CD40L system is also involved in tumorigenesis. Its expression is tightly regulated, and abnormal levels of CD40L are associated with the pathogenesis of atheromatous plaque destabilization and thrombotic events. Multiple mutations in CD40LG gene have been identified that are associated with hyper-IgM immunodeficiency syndrome type 1.


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