Collagen Type I Antibody 48 Publications

Rabbit Polyclonal| Catalog number: 14695-1-AP

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Con: 48 μg/150 μl

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Species specificity:
mouse, human, pig, rat, dog, rabbit

Positive WB detected in:
human kidney tissue, hVFFA8 cells

Positive IHC detected in:
human breast cancer tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
collagen, type I, alpha 2

Calculated molecular weight:
1366aa,130 kDa

Observed molecular weight:
160 kDa, 30 kDa, 129 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
COL1A2

Synonyms
Alpha 2 type I collagen, COL1A2, Collagen alpha 2(I) chain, Collagen Type I, collagen, type I, alpha 2, OI4
Background

Type I collagen, the major structural component of connective tissues such as skin, tendon and bone, is the most abundant and widely expressed collagen in humans (PMID: 7620364; 8645190; 9016532). Type I collagen is a heterotrimer comprising one alpha 2(I) and two alpha 1(I) chains which are encoded by the unlinked loci COL1A2 and COL1A1 respectively. Type I collagen has a molecular mass of about 250-300 kDa, while the alpha 2(I) chain has a molecular weight of about 100-130 kDa. Mutations in COL1A2 gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, idiopathic osteoporosis, and atypical Marfan syndrome.


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