Anti-Human CRHR1 Rabbit Recombinant Antibody, PBS Only

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  FC experiment of Transfected CHO-K1 using 98686-2-RR (same clone as 98686-2-PBS)

  1x10^6 CHO-K1 (left) or CRHR1-transfected CHO-K1 (right) were surface stained with 0.25 ug Anti-Human CRHR1 Rabbit RecAb (98686-2-RR, Clone: 251134A8) and PE-conjugated Goat Anti-Rabbit IgG. Cells were not fixed. This data was developed using the same antibody clone with 98686-2-PBS in a different storage buffer formulation.

• 

  FC experiment of Transfected CHO-K1 using 98686-2-RR (same clone as 98686-2-PBS)

  1x10^6 CHO-K1 (left) or CRHR1-transfected CHO-K1(right) were surface stained with 0.25 ug Anti-Human CRHR1 Rabbit RecAb (98686-2-RR, Clone: 251134A8) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-conjugated Goat Anti-Rabbit IgG. Cells were not fixed. This data was developed using the same antibody clone with 98686-2-PBS in a different storage buffer formulation.

CRHR1 Uni-rAb^® Recombinant Antibody for FC

Cat No. 98686-2-PBS

Clone No.251134A8

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

Corticotropin-releasing factor receptor 1, Corticotropin-releasing hormone receptor 1, CRF R, CRF R 1, CRF R1

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Product Information

98686-2-PBS targets CRHR1 in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: corticotropin releasing hormone receptor 1
• Calculated Molecular Weight: 48 kDa
• GenBank Accession Number: NM_004382
• Gene Symbol: CRHR1
• Gene ID (NCBI): 1394
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P34998
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Corticotropin-releasing hormone (CRH, also known as Corticotropin-releasing factor, CRF) is a 41 amino acid peptide hormone and a key regulator of the stress response. CRH and the related urocortin peptides (UCN, UCN2 and UCN3) mediate their actions through two mammalian receptor subtypes, CRHR1 and CRHR2 (PMID: 23863939). CRHR1 (also known as CRFR1) exhibits high affinity towards CRH and UCN but low affinity towards UCN2 and no affinity towards UCN3 (PMID: 22684850). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Widely distributed throughout the brain, CRHR1 critically controls behavioral adaptation to stress and is causally linked to emotional disorders (PMID: 21885734). Alternative splicing results in multiple transcript variants encoding distinct isoforms of CRHR1.