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CXCL12 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 17402-1-AP

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Con: 30 μg/150 μl

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Tested Applications
Applications:
ELISA, IF, IHC, WB
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CXCL12 Antibody IHC human liver cancer tissue 17402-1-AP

Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 17402-1-AP( CXCL12 Antibody) at dilution of 1:50 (under 10x lens)

CXCL12 Antibody IHC human liver cancer tissue 17402-1-AP

Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 17402-1-AP( CXCL12 Antibody) at dilution of 1:50 (under 40x lens)

Species specificity:
human, mouse
Positive IHC detected in:
human liver cancer tissue, human liver cancer tissue, human tonsillitis tissue
Recommended dilution:
IHC : 1:20-1:200

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
CXCL12 fusion protein ag11379
Full name:
chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)
Calculated molecular weight:
89aa,10 kDa
Observed molecular weight:
GenBank accession number:
BC039893
Gene ID (NCBI):
6387
Gene symbol
CXCL12
Synonyms
C X C motif chemokine 12, CXCL12, hIRH, hSDF 1, IRH, PBSF, SCYB12, SDF 1, SDF 1a, SDF 1b, SDF1, SDF1A, SDF1B, Stromal cell derived factor 1, TLSF a, TLSF b, TPAR1
Background

In adulthood, CXCL12 plays an important role in angiogenesis by recruiting endothelial progenitor cells (EPCs) from the bone marrow through a CXCR4 dependent mechanism (PMID: 17878755). It is this function of CXCL12 that makes it a very important factor in carcinogenesis and the neovascularisation linked to tumour progression (PMID: 16943240). CXCL12 also has a role in tumor metastasis where cancer cells that express the receptor CXCR4 are attracted to metastasis target tissues that release the ligand, CXCL12 (PMID: 11242036 ). In breast cancer, however, increased expression of CXCL12 determines a reduced risk of distant metastasis (PMID: 19646861; 17724466 ).


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