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CYR61/CCN1 Antibody 5 Publications

Rabbit Polyclonal| Catalog number: 26689-1-AP

Featured Product KD/KO validated

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Con: 50 μg/150 μl

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Tested Applications

Applications:
WB, IHC, IF, ELISA
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CYR61/CCN1 Antibody IF MCF-7 cells 26689-1-AP

Immunofluorescent analysis of ( -20°C Ethanol) fixed MCF-7 cells using 26689-1-AP (CYR61/CCN1 antibody) at dilution of 1:50 and Alexa Fluor 488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)

CYR61/CCN1 Antibody WB A431 cells 26689-1-AP

A431 cells were subjected to SDS PAGE followed by western blot with 26689-1-AP( CYR61/CCN1 antibody at dilution of 1:1500 incubated at room temperature for 1.5 hours

Species specificity:
human
Positive WB detected in:
A431 cells, MDA-MB-453s cells
Positive IHC detected in:
human colon cancer tissue, human ovary tumor tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected in:
MCF-7 cells, A431 cells
Recommended dilution:
WB : 1:500-1:3000
IHC : 1:50-1:500
IF : 1:50-1:500
Sample-dependent, check data in Validation tab

Protocols

Product-specific protocols

Standard Protocols

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
CYR61/CCN1 fusion protein Ag25129
Full name:
cysteine-rich, angiogenic inducer, 61
Calculated molecular weight:
42 kDa
Observed molecular weight:
42 kDa
GenBank accession number:
BC001271
Gene ID (NCBI):
3491
Gene symbol
CYR61
Synonyms
CCN family member 1, CCN1, CYR61, GIG1, IBP 10, IGF binding protein 10, IGFBP 10, IGFBP10, Protein CYR61, Protein GIG1

Background

CYR61 is a member of the CYR61/CTGF/NOV (CCN) protein family. CYR61 participated in cell mitogenesis, cellular adhesion, migration, differentiation, angiogenesis, and survival. Cyr61 is especially associated with diseases related to chronic inflammation, including RA, Crohn’s disease and ulcerative colitis. CYR61 may serve essential roles as either an oncogene or a tumor suppressor, depending on the cancer cell type. CYR61 also induces angiogenesis, which supplies oxygen and nutrients to tumors during growth. CYR61 can also play a role in the proliferation, invasion, survival, and metastasis of cancer cells.


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