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- KD/KO Validated
CYR61/CCN1 Polyclonal antibody
CYR61/CCN1 Polyclonal Antibody for IF, IHC, WB,ELISA
Host / Isotype
Rabbit / IgG
human and More (1)
WB, IHC, IF, ELISA
Cat no : 26689-1-AP
Validation Data Gallery
|Positive WB detected in||A431 cells, MDA-MB-453s cells, HeLa cells|
|Positive IHC detected in||human colon cancer tissue, human ovary tumor tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in||A431 cells|
|Western Blot (WB)||WB : 1:1000-1:4000|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
|KD/KO||See 3 publications below|
|WB||See 20 publications below|
|IHC||See 6 publications below|
|IF||See 5 publications below|
The immunogen of 26689-1-AP is CYR61/CCN1 Fusion Protein expressed in E. coli.
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||CYR61/CCN1 fusion protein Ag25129|
|Full Name||cysteine-rich, angiogenic inducer, 61|
|Calculated molecular weight||42 kDa|
|Observed molecular weight||42 kDa|
|GenBank accession number||BC001271|
|Gene ID (NCBI)||3491|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
CYR61 is a member of the CYR61/CTGF/NOV (CCN) protein family. CYR61 participated in cell mitogenesis, cellular adhesion, migration, differentiation, angiogenesis, and survival. Cyr61 is especially associated with diseases related to chronic inﬂammation, including RA, Crohn's disease and ulcerative colitis. CYR61 may serve essential roles as either an oncogene or a tumor suppressor, depending on the cancer cell type. CYR61 also induces angiogenesis, which supplies oxygen and nutrients to tumors during growth. CYR61 can also play a role in the proliferation, invasion, survival, and metastasis of cancer cells.
|Product Specific Protocols|
|WB protocol for CYR61/CCN1 antibody 26689-1-AP||Download protocol|
|IHC protocol for CYR61/CCN1 antibody 26689-1-AP||Download protocol|
|IF protocol for CYR61/CCN1 antibody 26689-1-AP||Download protocol|
|Click here to view our Standard Protocols|
A translational program that suppresses metabolism to shield the genome.
ACS Appl Mater Interfaces
A Novel Electrochemiluminescent Immunoassay Based on Target Transformation Assisted with Catalyzed Hairpin Assembly Amplification for the Ultrasensitive Bioassay.
Mol Ther Nucleic Acids
The RNA binding protein QKI5 suppresses ovarian cancer via downregulating transcriptional coactivator TAZ.
Cell Death Dis
EGFR-PI3K-PDK1 pathway regulates YAP signaling in hepatocellular carcinoma: the mechanism and its implications in targeted therapy.
WISP2/CCN5 Suppresses Vasculogenic Mimicry through Inhibition of YAP/TAZ Signaling in Breast Cancer Cells.
Hum Mol Genet
Abnormal activation of yap/Taz contributes to the pathogenesis of tuberous sclerosis complex.