|Positive WB detected in||HEK-293 cells, Raji cells|
|Positive FC detected in||HEK-293 cells|
|Western Blot (WB)||WB : 1:1000-1:4000|
|Sample-dependent, check data in validation data gallery|
The immunogen of 60239-1-Ig is Desmocollin 2 Fusion Protein expressed in E. coli.
|Tested Reactivity||human, mouse|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Desmocollin 2 fusion protein Ag5450|
|Full Name||desmocollin 2|
|Calculated molecular weight||100 kDa|
|Observed molecular weight||110 kDa|
|GenBank accession number||BC063291|
|Gene ID (NCBI)||1824|
|Purification Method||Protein A purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
Desmocollin 2 (DSC2) is a member of the desmocollin subfamily of the cadherin superfamily. The desmocollins (DSC1-3), along with the desmogleins (DSG1-4), are found primarily in epithelia and cardiac muscle where they constitute the adhesive proteins of the intercellular desmosome junctions and are required for cell adhesion and desmosome formation. Mutations in DSC2 gene are associated with arrhythmogenic right ventricular dysplasia-11.
Acta Physiol (Oxf)
Clustering of desmosomal cadherins by desmoplakin is essential for cell-cell adhesion.
Mol Ther Oncolytics
Exosomal miR-205-5p enhances angiogenesis and nasopharyngeal carcinoma metastasis by targeting desmocollin-2.
Stem Cell Res Ther
Both Wnt signaling and epidermal stem cell-derived extracellular vesicles are involved in epidermal cell growth.
Porphyromonas gingivalis induces penetration of lipopolysaccharide and peptidoglycan through the gingival epithelium via degradation of junctional adhesion molecule 1.
The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.
Jing (Verified Customer) (02-04-2020)
Tested in hiPSC-derived cardiomyocytes, it showed band around 130Kd.