DSCAML1 Polyclonal antibody

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  WB analysis using 32634-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 32634-1-AP (DSCAML1 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

DSCAML1 Polyclonal Antibody for WB, ELISA

Cat No. 32634-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

Cell adhesion molecule DSCAML1, Down syndrome cell adhesion molecule 2, Down syndrome cell adhesion molecule-like protein 1, DSCAM2, KIAA1132

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Tested Applications

• Positive WB detected in: 769-P cells, 786-O cells, Caki-1 cells, Caki-2 cells

Recommended dilution

• Western Blot (WB): WB : 1:500-1:3000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

32634-1-AP targets DSCAML1 in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag36336

  Product name: Recombinant human DSCAML1 protein

  Source: e coli.-derived, PET28a

  Tag: 6*His

  Domain: 1879-2053 aa of NM_020693

  Sequence: ADRGKNVAVPIPHRANKSDYCNLPLYAKSEAFFRKADGREPCPVVPPREASIRNLARTYHTQARHLTLDPASKSLGLPHPGAPAAASTATLPQRTLAMPAPPAGTAPPAPGPTPAEPPTAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMSTSGVGRSQKQGAGAYSKSYTLV

• Full Name: Down syndrome cell adhesion molecule like 1
• Calculated Molecular Weight: 224 kDa
• Observed Molecular Weight: 224 kDa
• GenBank Accession Number: NM_020693
• Gene Symbol: DSCAML1
• Gene ID (NCBI): 57453
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity Purification
• UNIPROT ID: Q8TD84
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Down syndrome cell adhesion molecule-like protein 1 (DSCAML1) is a transmembrane protein with ten immunoglobulin (Ig) and six fibronectin type III domains (PMID: 11453658). It is involved in neuronal cell adhesion and plays a crucial role in the development and function of the nervous system. DSCAML1 has been shown to participate in neuronal tiling, avoidance of neurite fasciculation, and axon guidance (PMID: 18216855; 21029858). Additionally, DSCAML1 is required for the proper placement of GABAergic neurons in the entorhinal cortex (ECx) and suppression of seizure susceptibility in rodents (PMID: 33256836).