Endoglin/CD105 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 10862-1-AP

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Freight/Packing

Con: 38 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse lung tissue, HUVEC cells

Positive IP detected in:
mouse lung tissue

Recommended dilution:
WB : 1:200-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
endoglin

Calculated molecular weight:
71 kDa

Observed molecular weight:
68-75 kDa, 170-180 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ENG

Synonyms
CD105, END, Endoglin, ENG, FLJ41744, HHT1, ORW, ORW1
Background

Endoglin (ENG, CD105) is a homodimeric cell membrane glycoprotein of 180 kDa, composed of disulphide-linked subunits of 95 kDa. Endoglin is a proliferation-associated and hypoxia-inducible protein mainly expressed on vascular endothelial cells. It acts as an accessory receptor for transforming growth factor beta (TFG-β) and is involved in vascular development and remodelling. The important role of Endoglin in angiogenesis and in tumor progression makes it an ideal target for antiangiogenic therapy and a good marker for tumor prognosis. (PMID: 1326540; 14528280; 21737653; 12773481)


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