|Positive WB detected in||Jurkat cells, NIH/3T3 cells, mouse thymus tissue|
|Western Blot (WB)||WB : 1:500-1:1000|
|Sample-dependent, check data in validation data gallery|
12118-1-AP targets ETS1 in WB, ELISA applications and shows reactivity with human, mouse samples.
|Tested Reactivity||human, mouse|
|Cited Reactivity||human, rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||ETS1 fusion protein Ag2127|
|Full Name||v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)|
|Calculated molecular weight||441 aa, 50 kDa|
|Observed molecular weight||50 kDa|
|GenBank accession number||BC017314|
|Gene ID (NCBI)||2113|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
ETS1 is a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. ETS1 is a nuclear protein and primarily acts as a transcriptional activator, though it can also repress gene transcription. Since it is primarily expressed in lymphocytes, it plays several critical roles in immunity. In addition, it is important for angiogenesis. Since cells express several Ets proteins at the same time, functional redundancy is possible. This is particularly shown for the socalled housekeeping genes where several Ets factors were found to occupy the proximal promoters in vivo. The ETS1 protein exists as three isoforms: ETS1-p51, ETS1-p42, ETS1-p27 ranging in size from 27 to 51 kDa.
p120 inhibits LPS/TNFα-induced endothelial Ang2 synthesis and release in an NF-κB independent fashion.
The histone demthylase KDM3A protects the myocardium from ischemia/reperfusion injury via promotion of ETS1 expression.
Int J Biol Sci
The RNF26/CBX7 axis modulates the TNF pathway to promote cell proliferation and regulate sensitivity to TKIs in ccRCC.
DOT1L promotes angiogenesis through cooperative regulation of VEGFR2 with ETS-1.
Front Cell Dev Biol
rSjP40 Inhibited the Activity of Collagen Type I Promoter via Ets-1 in HSCs.
HIV reprograms host m 6 Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1