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  • KD/KO Validated

ETS1 Polyclonal antibody

ETS1 Polyclonal Antibody for WB,ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB,ELISA

Conjugate

Unconjugated

Cat no : 12118-1-AP

Synonyms

ETS 1, ETS1, EWSR2, p54, Protein C ets 1



Tested Applications

Positive WB detected inJurkat cells, NIH/3T3 cells, mouse thymus tissue

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
Sample-dependent, check data in validation data gallery

Product Information

12118-1-AP targets ETS1 in WB,ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen ETS1 fusion protein Ag2127
Full Name v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
Calculated molecular weight 441 aa, 50 kDa
Observed molecular weight 50 kDa
GenBank accession numberBC017314
Gene symbol ETS1
Gene ID (NCBI) 2113
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

ETS1 is a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. ETS1 is a nuclear protein and primarily acts as a transcriptional activator, though it can also repress gene transcription. Since it is primarily expressed in lymphocytes, it plays several critical roles in immunity. In addition, it is important for angiogenesis. Since cells express several Ets proteins at the same time, functional redundancy is possible. This is particularly shown for the socalled housekeeping genes where several Ets factors were found to occupy the proximal promoters in vivo. The ETS1 protein exists as three isoforms: ETS1-p51, ETS1-p42, ETS1-p27 ranging in size from 27 to 51 kDa.

Protocols

Product Specific Protocols
WB protocol for ETS1 antibody 12118-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

Cytokine

p120 inhibits LPS/TNFα-induced endothelial Ang2 synthesis and release in an NF-κB independent fashion.

Authors - Ranran Li
  • KD Validated
humanWB

Oncotarget

DOT1L promotes angiogenesis through cooperative regulation of VEGFR2 with ETS-1.

Authors - Yang Duan