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  • KD/KO Validated

EXOSC4 Polyclonal antibody

EXOSC4 Polyclonal Antibody for WB, IF, IHC, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat





Cat no : 15937-1-AP


EXOSC4, exosome component 4, hRrp41p, p12A, RRP41, RRP41A, Rrp41p, SKI6, Ski6p

Tested Applications

Positive WB detected inHEK-293T cells, Jurkat cells, HeLa cells, SW480 cells, HCT 116 cells, mouse liver tissue, rat liver tissue
Positive IHC detected inhuman skin cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inHepG2 cells

Recommended dilution

Western Blot (WB)WB : 1:1000-1:8000
Immunohistochemistry (IHC)IHC : 1:400-1:1600
Immunofluorescence (IF)IF : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

15937-1-AP targets EXOSC4 in WB, IF, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen EXOSC4 fusion protein Ag7595
Full Name exosome component 4
Calculated Molecular Weight 26 kDa
Observed Molecular Weight 27 kDa
GenBank Accession NumberBC002777
Gene Symbol EXOSC4
Gene ID (NCBI) 54512
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

EXOSC4, also named as RRP41 and SKI6, belongs to the RNase PH family. EXOSC4 is a novel component of the human exosome complex. EXOSC4 is the most important RNA processing machinery in maturation and degradation of RNA playing a major role in gene expression regulation (PMID: 29626590). EXOSC4 has 1 isoform with the molecular mass of 27 kDa. However, studies have shown that EXOSC4 can interact with EXOSC2 and EXOSC7, possibly form a complex with the molecular weight of 90 kDa (PMID: 25115889). Recently, EXOSC4 has been found to play important roles in tumorigcncsis and development including CRC (PMID: 33075373).


Product Specific Protocols
WB protocol for EXOSC4 antibody 15937-1-APDownload protocol
IHC protocol for EXOSC4 antibody 15937-1-APDownload protocol
IF protocol for EXOSC4 antibody 15937-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



J Biol Chem

A Point Mutation in the Exon Junction Complex Factor Y14 Disrupts Its Function in mRNA Cap Binding and Translation Enhancement.

Authors - Tzu-Wei Chuang

Life Sci

STX2 drives colorectal cancer proliferation via upregulation of EXOSC4.

Authors - Yong-Xia Wang
  • KD Validated

Life Sci Alliance

Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication

Authors - Tobias Moll


The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.


Tsimafei (Verified Customer) (07-06-2022)

Control and Exosc4 depletion shows a reduction of Exosc4 signal. Antibodies were incubated ON at 4C.

  • Applications: Western Blot
  • Primary Antibody Dilution: 1:2000
  • Cell Tissue Type: mESCs
EXOSC4 Antibody Western Blot validation (1:2000 dilution) in mESCs (Cat no:15937-1-AP)