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  • KD/KO Validated

FGFR4 Polyclonal antibody

FGFR4 Polyclonal Antibody for WB, IF, IHC, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat





Cat no : 11098-1-AP



Tested Applications

Positive WB detected inHepG2 cells, mouse lung tissue
Positive IHC detected inhuman breast cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inHepG2 cells

Recommended dilution

Western Blot (WB)WB : 1:200-1:1000
Immunohistochemistry (IHC)IHC : 1:50-1:500
Immunofluorescence (IF)IF : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

11098-1-AP targets FGFR4 in WB, IF, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen FGFR4 fusion protein Ag1573
Full Name fibroblast growth factor receptor 4
Calculated Molecular Weight 88 kDa
Observed Molecular Weight 100-110 kDa
GenBank Accession NumberBC011847
Gene Symbol FGFR4
Gene ID (NCBI) 2264
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Fibroblast growth factor receptor 4 (FGFR4) is a member of a highly conserved tyrosine kinase family, along with FGFR1-3. This family consists of an intracellular tyrosine kinase domain, a single transmembrane domain, and extracellular ligand binding domains (PMID:32492514). FGFR4 is the predominant FGFR isoform present in human hepatocytes. FGFR4 has been proposed to play a role in the observed induction of hepatocyte proliferation and carcinogenesis by FGF19; however, contradicting evidence proposing a protective role for FGFR4 in suppressing hepatoma progression has also been proposed(PMID:20018895). While the role of FGFR4 in cancer remains to be fully elucidated, several findings suggest that this receptor may be an important player in Hepatocellular carcinoma (HCC) development and/or progression(PMID:10336501).


Product Specific Protocols
WB protocol for FGFR4 antibody 11098-1-APDownload protocol
IHC protocol for FGFR4 antibody 11098-1-APDownload protocol
IF protocol for FGFR4 antibody 11098-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



J Med Chem

FGF19-Based Mini Probe Targeting FGFR4 for Diagnosis and Surgical Navigation of Hepatocellular Carcinoma

Authors - Jiaxian Cai
  • KD Validated

Biochem Pharmacol

Association between the perturbation of bile acid homeostasis and valproic acid-induced hepatotoxicity.

Authors - Yanan Chen

Biomed Pharmacother

Bupleuri radix extract ameliorates impaired lipid metabolism in high-fat diet-induced obese mice via gut microbia-mediated regulation of FGF21 signaling pathway.

Authors - Liucen Wu

J Cell Biochem

Glycosylation of FGFR4 in cholangiocarcinoma regulates receptor processing and cancer signaling.

Authors - Andrew J Phillips
humanIHC, WB

Int J Oncol

Role of fibroblast growth factor 4 in the growth and metastasis of colorectal cancer.

Authors - Yanwei Ye

Cancer Res Treat

FGFR4 Gly388Arg Polymorphism Affects the Progression of Gastric Cancer by Activating STAT3 Pathway to Induce Epithelial to Mesenchymal Transition.

Authors - Yanwei Ye