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FXYD6 Polyclonal antibody

FXYD6 Polyclonal Antibody for WB, IHC, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat





Cat no : 15805-1-AP


FXYD6, Phosphohippolin

Tested Applications

Positive WB detected inPC-12 cells, mouse brain tissue, human brain tissue, human testis tissue, rat brain tissue, SH-SY5Y cells
Positive IHC detected inhuman brain tissue, human liver tissue, human ovary tissue, human skin tissue, human spleen tissue, human testis tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

Western Blot (WB)WB : 1:500-1:3000
Immunohistochemistry (IHC)IHC : 1:20-1:200
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

15805-1-AP targets FXYD6 in WB, IF, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen FXYD6 fusion protein Ag8538
Full Name FXYD domain containing ion transport regulator 6
Calculated Molecular Weight 95 aa, 11 kDa
Observed Molecular Weight 20 kDa
GenBank Accession NumberBC018652
Gene Symbol FXYD6
Gene ID (NCBI) 53826
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

The FXYD family is a group of small single-span transmembrane proteins characterized by a signature sequence containing an FXYD motif, two conserved glycines and a serine residue. Members of the FXYD family, including FXYD1 (phospholemman), FXYD2 (gamma subunit of Na,K-ATPase), FXYD3 (Mat8), FXYD4 (CHIF), FXYD5 (RIC), FXYD6 (phosphohippolin) and FXYD7, are tissue specific regulators of the Na,K-ATPase. FXYD6 is primarily expressed in the brain. It modulates the kinetic activity of Na,K-ATPase and has long-term physiological importance in maintaining cation homeostasis. It may play a role in endolymph composition and has a potential important role in neuronal excitability of the CNS during postnatal development and in the adult brain. On the SDS-PAGE FXYD6 migrates with an apparent molecular weight of approximately 20 kDa, which is larger than the calculated molecular weight of 10.5 kDa (PMID: 15193427; 17209044). The gene encodes FXYD6 is located on chromosome 11q23.3, and it might be a susceptibility gene of schizophrenia.


Product Specific Protocols
WB protocol for FXYD6 antibody 15805-1-APDownload protocol
IHC protocol for FXYD6 antibody 15805-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



J Am Soc Nephrol

Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation.

Authors - Sébastien J Dumas

Cancer Med

Identification of FXYD6 as the novel biomarker for glioma based on differential expression and DNA methylation

Authors - Weiliang Hou

Biomed Res Int

FXYD6 Regulates Chemosensitivity by Mediating the Expression of Na+/K+-ATPase α1 and Affecting Cell Autophagy and Apoptosis in Colorectal Cancer.

Authors - Wen Luo
  • KD Validated