BMP9 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 17769-1-AP

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Freight/Packing

Con: 34 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
L02 cells, Transfected HEK-293 cells

Positive IHC detected in:
human hepatocirrhosis tissue, human liver cancer tissue

Recommended dilution:
WB : 1:200-1:1000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
growth differentiation factor 2

Calculated molecular weight:
429aa,47 kDa

Observed molecular weight:
30 kDa, 46 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
GDF2

Synonyms
BMP 9, BMP9, Bone morphogenetic protein 9, GDF 2, GDF2
Background

BMP9 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia. Human BMP9 precursor protein contains 429 amino acids and has a calculated molecular mass of about 47 kD. Posttranslational processing results in a mature BMP9 protein of about 13 kD. Once secreted, BMP9 may exist as dimers of mature regions or as BMP9 proregion complexes in which the proregion of BMP9 remains tightly associated with the mature dimer.


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