HOPX Polyclonal Antibody for IHC, WB, ELISA
Cat no : 11419-1-AP
CAMEO, HOD, Homeodomain only protein, HOP, HOP homeobox, HOPX, LAGY, NECC1, OB1, Odd homeobox protein 1, SMAP31, TOTO
|Positive WB detected in||mouse lung tissue|
|Positive IHC detected in||human lung cancer tissue, human skin cancer tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:200-1:1000|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
11419-1-AP targets HOPX in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||HOPX fusion protein Ag1979|
|Full Name||HOP homeobox|
|Calculated molecular weight||73 aa, 8 kDa|
|Observed molecular weight||8-12 kDa|
|GenBank accession number||BC014225|
|Gene ID (NCBI)||84525|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
HOPX (Homeodomain-only protein) gene has various synonyms including HOD, HOP, OB1, LAGY and NECC1. The protein encoded by this gene is an unusual homeodomain protein that lacks certain conserved residues required for DNA binding. HOPX has diverse effects on cardiac growth. Manipulation of Hopx function in murine models is associated with cardiac hypertrophy, dilation and fibrosis. HOPX protein acts as an antagonist to the serum response factor (SRF), which regulates the opposing processes of cell proliferation and differentiation. Overexpression of HOPX causes cardiac hypertrophy. HOPX protein can inhibit SRF-dependent transcriptional activation by recruiting histone deacetylase (HDAC) activity.
Acta Neuropathol Commun
Assessment of radial glia in the frontal lobe of fetuses with Down syndrome.
Molecular Signatures of a TLR4 Agonist-Adjuvanted HIV-1 Vaccine Candidate in Humans.
YAP1/TAZ drives ependymoma-like tumour formation in mice.
Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis.
Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma.
Origins and Proliferative States of Human Oligodendrocyte Precursor Cells.
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Nicole (Verified Customer) (07-23-2019)
Used to mark stem cell cultures for differentiation into neural like cells