Mouse Hepsin Polyclonal antibody, PBS Only

• 

  WB analysis of human liver using 51060-1-Ig (same clone as 51060-1-PBS)

  human liver tissue were subjected to SDS PAGE followed by western blot with 51060-1-Ig (Hepsin antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 51060-1-PBS in a different storage buffer formulation.

• 

  WB analysis of mouse liver using 51060-1-Ig (same clone as 51060-1-PBS)

  mouse liver tissue were subjected to SDS PAGE followed by western blot with 51060-1-Ig (Hepsin antibody) at dilution of 1:0 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 51060-1-PBS in a different storage buffer formulation.

Hepsin Polyclonal Antibody for WB, Indirect ELISA

Cat No. 51060-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Synonyms

Hpn, AI788568, EC:3.4.21.106, Serine protease hepsin non-catalytic chain, TMPRSS 1

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Product Information

51060-1-PBS targets Hepsin in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: hepsin
• Calculated Molecular Weight: 47 kDa
• Observed Molecular Weight: 28 kDa
• GenBank Accession Number: BC138809
• Gene Symbol: Hepsin
• Gene ID (NCBI): 15451
• RRID: AB_763181
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: O35453
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Hepsin is a type II transmembrane serine protease. It is primarily expressed in the liver but has also been detected in other tissues, including the prostate, kidney, and pancreas. Hepsin plays a crucial role in various physiological processes, such as cell growth, extracellular matrix remodeling, and tissue homeostasis. Notably, Hepsin has been implicated in cancer progression, particularly in prostate cancer, where its overexpression is associated with tumor metastasis and poor prognosis (PMID: 15324701, PMID: 18726901). Hepsin has been identified as a peptide of approximately 45 kDa representing the intact protein, and a fragment of about 28 kDa representing the cleaved extracellular domain (PMID: 19302215, PMID: 21734266).